Despite advances in the understanding of biological systems, drug discovery is still a long process (drugs research contract). Whilst information on the human genome, its sequence and what it encodes has been hailed as the answer to virtually eliminate the bottleneck in therapeutic targets, the full potential is still a long way off.
The tool consists of a search engine that is connected to a giant database. The intention is the two elements work in A new era of dual-use condoms tandem to connect human diseases with potential drugs to treat them, as well as predict how new drugs work in human cells.
Scientists have come up with an innovative tool that may accelerate the drug development process (drugs R&D), which has slowed down considerably despite the investment in new technologies and analytical techniques.
The tool, known as Connectivity (drugs research) Map allows researchers to screen compounds against genome wide disease signatures, rather than a pre-selected set of target genes.
Drugs are paired with diseases using sophisticated pattern-matching methods with a high level of resolution and specificity. CRO blog.
"This is a powerful discovery tool for the scientific community," said Justin Lamb, the lead author of the paper, published in Science.
The Connectivity Map is the work of The Broad Institute, a research collaboration involving faculty, professional staff and students from throughout the Massachusetts Institute of Technology (medical experimental) and Harvard academic and medical communities and is governed jointly by the two universities. Cancer cell membrane protein structure was first discovered.
The Connectivity Map is the subject of three new research papers that are published in the journals Science and Cancer Cell.
"By analysing just a small fraction of available drugs, we have already confirmed several biological connections between drugs and human disease, and made entirely new ones, too," he added.
This research effort aims to generate a detailed map that links gene patterns associated with disease to corresponding patterns produced by drug candidates and a variety of genetic manipulations. JamJaa.com.
